ANGPTL8 protein-truncating variant and the risk of coronary disease, type 2 diabetes and adverse effects. Pyry Helkkula, Tuomo Kiiskinen, Aki S. Havulinna, Juha Karjalainen, Seppo Koskinen, Veikko Salomaa, FinnGen, Mark J. Daly, Aarno Palotie, Ida Surakka, Samuli Ripatti (2021), PLoS Genetics. Link to publication, doi: https://doi.org/10.1101/2020.06.09.20125278
Polygenic burden has broader impact on health, cognition, and socioeconomic outcomes than most rare and high-risk copy number variants. Elmo Christian Saarentaus, Aki Samuli Havulinna, Nina Mars, Ari Ahola-Olli, Tuomo Tapio Johannes Kiiskinen, Juulia Partanen, Sanni Ruotsalainen, Mitja Kurki, Lea Martta Urpa, Lei Chen, Markus Perola, Veikko Salomaa, Juha Veijola, Minna Männikkö, Ira M. Hall, Olli Pietiläinen, Jaakko Kaprio, Samuli Ripatti, Mark Daly & Aarno Palotie (2021). Molecular Psychiatry. Link to publication, doi: https://doi.org/10.1038/s41380-021-01026-z
Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers. Nina Mars, Jukka T. Koskela, Pietari Ripatti, Tuomo T. J. Kiiskinen, Aki S. Havulinna, Joni V. Lindbohm, Ari Ahola-Olli, Mitja Kurki, Juha Karjalainen, Priit Palta, Benjamin M. Neale, Mark Daly, Veikko Salomaa, Aarno Palotie, Elisabeth Widén, Samuli Ripatti (2020), Nature Medicine. Link to publication, doi: 10.1038/s41591-020-0800-0
Increasing the Clinical Psychiatric Knowledge Base About Pathogenic Copy Number Variation. Patrick F. Sullivan, Michael J. Owen (2020), American Journal of Psychiatry. Link to publication, doi: 10.1176/appi.ajp.2019.19040335
Protocol for the Standardized Generation of Forward Programmed Cryopreservable Excitatory and Inhibitory Forebrain Neurons. Michael Peitz, Tamara Krutenko, Oliver Brüstle (2020), STAR Protocols. Link to publication, doi: 10.1016/j.xpro.2020.100038
The role of polygenic risk and susceptibility genes in breast cancer over the course of life. Nina Mars, Elisabeth Widén, Sini Kerminen, Tuomo Meretoja, Matti Pirinen, Pietro Della Briotta Parolo, Priit Palta, FinnGen; Aarno Palotie, Jaakko Kaprio, Heikki Joensuu, Mark Daly, Samuli Ripatt (2020), Nature Communications. Link to publication, doi: https://doi.org/10.1038/s41467-020-19966-5
Homozygous STXBP1 variant causes encephalopathy and gain-of-function in synaptic transmission. Hanna C A Lammertse, Annemiek A van Berkel, Michele Iacomino, Ruud F Toonen, Pasquale Striano, Antonio Gambardella, Matthijs Verhage, Federico Zara (2019), Brain. Link to publication, doi: 10.1093/brain/awz391
Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland. Mitja I. Kurki, Elmo Saarentaus, Olli Pietiläinen, Padhraig Gormley, Dennis Lal, Sini Kerminen, Minna Torniainen-Holm, Eija Hämäläinen, Elisa Rahikkala, Riikka Keski-Filppula, Merja Rauhala, Satu Korpi-Heikkilä, Jonna Komulainen–Ebrahim, Heli Helander, Päivi Vieira, Minna Männikkö, Markku Peltonen, Aki S. Havulinna, Veikko Salomaa, Matti Pirinen, Jaana Suvisaari, Jukka S. Moilanen, Jarmo Körkkö, Outi Kuismin, Mark J. Daly, Aarno Palotie (2019), Nature Communications. Link to publication, doi: 10.1038/s41467-018-08262-y
Evolving principles underlying neural lineage conversion and their relevance for biomedical translation. Lea Jessica Flitsch, Oliver Brüstle (2019), F1000Research. Link to publication, doi: 10.12688/f1000research.18926.1
A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons. Marieke Meijer, Kristina Rehbach, Jessie W. Brunner, Jessica A. Classen, Hanna C.A. Lammertse, Lola A. van Linge, Desiree Schut, Tamara Krutenko, Matthias Hebisch, L. Niels Cornelisse, Patrick F. Sullivan, Michael Peitz, Ruud F. Toonen, Oliver Brüstle, Matthijs Verhage (2019), Cell Reports. Link to publication, doi: 10.1016/j.celrep.2019.04.058
An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons. Hong Jun Rhee, Ali H. Shaib, Kristina Rehbach, ChoongKu Lee, Peter Seif, Carolina Thomas, Erinn Gideons, Anja Guenther, Tamara Krutenko, Matthias Hebisch, Michael Peitz, Nils Brose, Oliver Brüstle, Jeong Seop Rhee (2019), Cell Reports. Link to publication, doi: 10.1016/j.celrep.2019.04.059
Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders. Patrick F. Sullivan, Daniel H. Geschwind (2019), Cell. Link to publication, doi: 10.1016/j.cell.2019.01.015
MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis. Laura Stappert, Frederike Klaus, Oliver Brüstle (2018), Frontiers in Neuroscience. Link to publication, doi: 10.3389/fnins.2018.00707
Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells. The International Stem Cell Initiative: Allison, T.F., Andrews, P.W., Avior, Y., Barbaric, I., Benvenisty, N., Bock, C., Brehm, J., Brüstle, O., Damjanov, I., Elefanty, A., Felkner, D., Gokhale, P.J., Halbritter, F., Healy, L.E., Hu, T.X., Knowles, B.B., Loring, J.F., Ludwig, T.E., Mayberry, R., Micallef, S., Mohamed, J.S., Müller, F.-J., Mummery, C.L., Nakatsuji, N., Ng, E.S., Oh, S.K.W., O’Shea, O., Pera, M.F., Reubinoff, B., Robson, P., Rossant, J., Schuldt, B.M., Solter, D., Sourris, K., Stacy, G., Stanley, E.G., Suemori, H., Takahashi, K., Yamanaka, S. (2018), Nature Cummunications. Link to publication, doi: https://doi.org/10.1038/s41467-018-04011-3
Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation. Beate Roese-Koerner, Laura Stappert, Oliver Brüstle (2017), Neurogenesis. Link to publication, doi: 10.1080/23262133.2017.1313647
Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy. Johannes Jungverdorben, Andreas Till, Oliver Brüstle (2017), Journal of Molecular Medicine. Link to publication, doi: 10.1007/s00109-017-1533-5
Whole-brain 3D mapping of human neural transplant innervation. Jonas Doerr, Martin Karl Schwarz, Dirk Wiedermann, Anke Leinhaas, Alina Jakobs, Florian Schloen, Inna Schwarz, Michael Diedenhofen, Nils Christian Braun, Philipp Koch, Daniel A. Peterson, Ulrich Kubitscheck, Mathias Hoehn, Oliver Brüstle (2017), Nature Communications. Link to publication, doi: 10.1038/ncomms14162
Modeling psychiatric disorders: from genomic findings to cellular phenotypes. Falk A, Heine VM, Harwood AJ, Sullivan PF, Peitz M, Brüstle O, Shen S, Sun YM, Glover JC, Posthuma D, Djurovic S. (2016), Molecular Psychiatry. Link to publication, doi: 10.1038/mp.2016.89